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Case Series
Plasma cell vaginitis and cervicitis
1 MSc, Physician’s Assistant Student, Mercer University College of Health Professions, Atlanta, GA, USA
2 BS, Medical Student, Marian University College of Osteopathic Medicine, Indianapolis, IN, USA
3 MD, MEd, Associate Director, The Centers for Vulvovaginal Disorders, Washington, DC, USA
4 MSc, Medical Student, St. George University School of Medicine, True Blue, Grenada
5 BS, Practice Manager, The Centers for Vulvovaginal Disorders, Washington, DC, USA
6 MD, Director, The Centers for Vulvovaginal Disorders, Washington, DC, USA
7 Clinical Professor, Department of Obstetrics and Gynecology, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA
Address correspondence to:
Jill M Krapf
MD, MEd, The Centers for Vulvovaginal Disorders, 3 Washington Circle NW, Suite 205, Washington, DC 20037,
USA
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Article ID: 100065Z08LM2020
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How to cite this article
Mitchell LS, Barela K, Krapf JM, Govind V, Tolson H, Goldstein AT. Plasma cell vaginitis and cervicitis. J Case Rep Images Obstet Gynecol 2020;6: 100065Z08LM2020.ABSTRACT
Introduction: Plasma cell vulvitis (PCV), also known as Zoon’s vulvitis, is a rare, chronic inflammatory disease characterized by erythematous plaques with a red, orange hue and increased plasma cells typically affecting the vulva.
Case Series: This case series details two clinical presentations of plasma cell mucositis affecting the vagina and cervix, resulting in copious, purulent vaginal discharge. Vaginal and cervical histopathologic findings of a plasmacytic infiltrate confirmed the diagnosis of plasma cell mucositis. Both women were successfully treated with a vaginal estradiol/hydrocortisone/clindamycin cream and experienced complete resolution of symptoms and physical exam findings.
Conclusion: Plasma cell mucositis may be present on the vulva, vagina, and cervix.
Keywords: Cervicitis, Plasma cell mucositis, Plasma cell vulvitis, Vulvovaginitis, Zoon’s vulvitis
SUPPORTING INFORMATION
Author Contributions
Leia S Mitchell - Substantial contributions to conception and design, Acquisition of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Karissa Barela - Acquisition of data, Revising it critically for important intellectual content, Final approval of the version to be published
Jill M Krapf - Acquisition of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Vaishnavi Govind - Revising it critically for important intellectual content, Final approval of the version to be published
Hillary Tolson - Acquisition of data, Revising it critically for important intellectual content, Final approval of the version to be published
Andrew T Goldstein - Substantial contributions to conception and design, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Guaranter of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestLeia Mitchell, Hillary Tolson, Vaishnavi Govind, and Jill Krapf report no conflicts of interest. Andrew Goldstein is a consultant to SST, Dare, Ipsen, Grunenthal and has received research funding from Elen, Ipsen, Endoceutics, Grunenthal, Dare, and SST.
Copyright© 2020 Leia S Mitchell et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
