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Case Report
Anti-N-methyl-D-aspartate receptor encephalitis in pregnancy: An interesting case of rapid contralateral ovarian teratoma development
1 Department of OBGYN, Department of OBGYN, Medical University of South Carolina, USA
2 Department of OBGYN, Medical University of South Carolina, 96 Jonathan Lucas St, Charleston, SC 29425, USA
3 Department of Neurology, Medical University of South Carolina, 96 Jonathan Lucas St, Charleston, SC 29425, USA
4 Medical University of South Carolina, Department of Maternal Fetal Medicine, 96 Jonathan Lucas St, Charleston, SC 29425, USA
Address correspondence to:
Catherine Boniface
MD, Department of OBGYN, Medical University of South Carolina, 96 Jonathan Lucas St, Charleston, SC 29425,
USA
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Article ID: 100091Z08CB2021
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How to cite this article
Boniface C, Austin B, Chalela J, Newman R. Anti-N-methyl-D-aspartate receptor encephalitis in pregnancy: An interesting case of rapid contralateral ovarian teratoma development. J Case Rep Images Obstet Gynecol 2021;7:100091Z08CB2021.ABSTRACT
Introduction: Anti-NMDAR encephalitis is a newly described form of paraneoplastic encephalitis and is known to be associated with ovarian teratomas.
Case Report: Here we describe a previously healthy 22-year-old patient who was affected by anti-NMDAR encephalitis during pregnancy. She was diagnosed with an ovarian teratoma which was successfully removed and confirmed by pathology. She rapidly developed a contralateral teratoma after removal of the first despite previously negative imaging and operative examination of the contralateral ovary. Her clinical status improved after bilateral salpingo-oophorectomy.
Conclusion: If a paraneoplastic encephalitis is suspected, careful re-evaluation for possible teratomas should be considered, especially in cases of clinically worsening or plateauing neurologic status.
Keywords: Anti-NMDAR encephalitis, Ovarian teratoma, Pregnancy
SUPPORTING INFORMATION
Author Contributions
Catherine Boniface - Substantial contributions to conception and design, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Brittany Austin - Substantial contributions to conception and design, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Julio Chalela - Analysis of data, Revising it critically for important intellectual content, Final approval of the version to be published
Roger Newman - Substantial contributions to conception and design, Revising it critically for important intellectual content, Final approval of the version to be published
Guaranter of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2021 Catherine Boniface et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
