 |
Case Report
Pancreatic ductal adenocarcinoma (intestinal-type differentiation) presenting as ovarian metastases: A case report
1 Medical Student, University of Virginia School of Medicine, Charlottesville, Virginia, USA
2 Resident, Department of Obstetrics and Gynecology, University of Virginia, Charlottesville, Virginia, USA
3 Fellow, Department of Pathology, University of Virginia, Charlottesville, Virginia, USA
4 Associate Professor, Department of Pathology, University of Virginia, Charlottesville, Virginia, USA
5 Professor, Department of Obstetrics and Gynecology, University of Virginia, Charlottesville, Virginia, USA
Address correspondence to:
Emily Fronk
University of Virginia School of Medicine, 1215 Lee Street, Charlottesville, VA 22903,
USA
Message to Corresponding Author
Article ID: 100159Z08EF2023
Access full text article on other devices
Access PDF of article on other devices
How to cite this article
Fronk E, Welp A, Dibbern M, Mills A, Cantrell L. Pancreatic ductal adenocarcinoma (intestinal-type differentiation) presenting as ovarian metastases: A case report. J Case Rep Images Obstet Gynecol 2023;9(2):25–29.ABSTRACT
Introduction: Metastasis of pancreatic adenocarcinoma to the ovaries is uncommon and can clinically present similarly to primary ovarian disease, presenting challenges for diagnosis. Immunohistochemical staining is typically useful in distinguishing ovarian primaries from ovarian metastasis. A newer and rarer variant of pancreatic adenocarcinoma, that with intestinal-type differentiation, has not previously been reported as metastasizing to the ovary. Its diagnosis is particularly difficult due to the overlap in staining patterns with primary ovarian neoplasms.
Case Report: This case report presents the case of a 60-year-old female who presented with non-specific abdominal symptoms and was found to have a large adnexal mass. Imaging showed additional lesions in the peritoneum, pancreas, and liver. She underwent biopsy with morphology and immunohistochemical staining consistent with pancreatic ductal adenocarcinoma with intestinal-type differentiation. She was started on FOLFIRINOX therapy but ultimately opted to pursue comfort care due to disease progression.
Conclusion: Although rare, with this being the first report of this disease course to our knowledge, clinicians should be aware of this possibility, as it impacts choice of treatment.
Keywords: Immunohistochemical staining, Ovarian metastasis, Pancreatic adenocarcinoma
SUPPORTING INFORMATION
Author Contributions
Emily Fronk - Substantial contributions to conception and design, Drafting the article, Final approval of the version to be published
Annalyn Welp - Substantial contributions to conception and design, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Megan Dibbern - Substantial contributions to conception and design, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Anne Mills - Substantial contributions to conception and design, Drafting the article, Final approval of the version to be published
Leigh Cantrell - Substantial contributions to conception and design, Drafting the article, Final approval of the version to be published
Guaranter of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2023 Emily Fronk et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
