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Case Report
Spontaneous hemorrhage of peripheral neurofibroma in pregnancy: A case report
1 Department of Obstetrics & Gynecology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
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Kira A Bromwich
MD, Department of OBGYN, Hospital of the University of Pennsylvania, 3400 Spruce Street, 5 Dulles, Philadelphia, PA 19104-6160,
USA
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Article ID: 100172Z08KB2024
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Bromwich KA, Rush M, Janssen M, Hirshberg A. Spontaneous hemorrhage of peripheral neurofibroma in pregnancy: A case report. J Case Rep Images Obstet Gynecol 2024;10(1):34–37.ABSTRACT
Introduction: Neurofibromas may grow in pregnancy due to hormonal sensitivity. This report describes a case of spontaneous hemorrhage from a neurofibroma in pregnancy.
Case Report: A 27-year-old female with neurofibromatosis (NF1) presented at 30 weeks gestation with shortness of breath. Spontaneous hemorrhage was noted from her left leg neurofibroma. The patient underwent preprocedural fetal surveillance prior to proceeding with surgical debridement. Persistent fetal bradycardia was noted in setting of maternal hypotension with ongoing bleeding. An emergent cesarean delivery was performed and required debridement of the left thigh neurofibroma by the general surgical team.
Conclusion: Spontaneous hemorrhage of neurofibromas is a rare, but reported complication. Neurofibromas may increase in size in pregnancy; however, spontaneous hemorrhage has not previously been documented to occur during pregnancy.
Keywords: Hemorrhage, Neurofibroma, Neurofibromatosis, NF1, Pregnancy, Spontaneous
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Author Contributions
Kira A Bromwich - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Margaret Rush - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Matthew Janssen - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Adi Hirshberg - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Guaranter of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2024 Kira A Bromwich et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
