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Case Series
Ultrasound findings in pregnancies affected by placental perivillous fibrin deposition: A case series
1 OBGYN Resident, Advocate Lutheran General Hospital, Park Ridge, IL 60068, USA
2 Maternal Fetal Medicine Physician, Advocate Lutheran General Hospital, Park Ridge, IL 60068, USA
3 Maternal Fetal Medicine Physician, Advocate Christ Medical Center, Oak Lawn, IL 60453, USA
Address correspondence to:
Olivia Garcia
DO, Obstetrics & Gynecology Department, Advocate Lutheran General Hospital, Park Ridge, IL 60068,
USA
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Article ID: 100178Z08OG2024
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Garcia O, Kase B, Harrison R, Holmgren C. Ultrasound findings in pregnancies affected by placental perivillous fibrin deposition: A case series. J Case Rep Images Obstet Gynecol 2024;10(2):13–17.ABSTRACT
Introduction: This article presents unique ultrasound findings in patients with perivillous fibrin deposition on placental pathology. Massive perivillous fibrin deposition (MPVFD), characterized by excessive deposition of fibrinoid material in the placenta, is a rare finding on pathologic investigation and has been associated with gestational morbidity and mortality.
Case Series: We present three cases with abnormal prenatal ultrasound findings that were formally diagnosed with excessive perivillous fibrin deposition by postnatal pathologic specimen review. Cases 1 and 2 are of the same patient following subsequent pregnancies. The first pregnancy resulted in new fetal growth restriction, necessitating delivery at 34 weeks. The second pregnancy then warranted close sonographic monitoring. This pregnancy was overall uncomplicated until placental cysts appeared at 31 weeks. She had antenatal testing until her planned delivery at 37 weeks. Placental abnormality was noted at 24 weeks in the third case. She ultimately was delivered at 35 weeks with fetal growth restriction, non-reassuring fetal status, and preeclampsia with severe features.
Conclusion: Placental perivillous fibrin deposition is clinically significant given risks for fetal growth restriction and preterm delivery for fetal indications. Therefore, when ultrasound findings are suggestive of this pathology, the obstetrician should be prompted to increase surveillance of the given pregnancy.
Keywords: Case series, Fetal growth restriction, Fibrin deposition, Obstetrics, Placental pathology, Pregnancy, Ultrasound
SUPPORTING INFORMATION
Author Contributions
Olivia Garcia - Substantial contributions to conception and design, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Benjamin Kase - Analysis of data, Interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
Rachel Harrison - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Calla Holmgren - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Guaranter of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2024 Olivia Garcia et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
