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Case Report
Ovarian and fallopian tube yolk sac tumor in postmenopausal patient: Case report and review of literature
1 Department of Gynaecology and Obstetrics, Hospital Materno Infantil de Badajoz, Badajoz 06010, Spain
2 Department of Anatomic Pathology, Hospital Perpetuo Socorro de Badajoz, Badajoz 06010, Spain
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Gloria LópezPérez
Department of Gynaecology and Obstetrics, Hospital Materno Infantil de Badajoz, Calle Flores 10, 1ºD, Badajoz 06010,
Spain
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Article ID: 100233Z08GP2026
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How to cite this article
Pérez GL, Iglesias PER, Marín RG, Nieto EH, Caballero MCT. Ovarian and fallopian tube yolk sac tumor in postmenopausal patient: Case report and review of literature. J Case Rep Images Obstet Gynecol 2026;12(1):59–64.ABSTRACT
Introduction: Ovarian yolk sac tumors are uncommon malignant germ cell neoplasms that occur predominantly in young women. Their occurrence in postmenopausal women is exceedingly rare. Elevated serum alpha-fetoprotein (AFP) remains the key diagnostic and surveillance marker.
Case Report: A 58-year-old postmenopausal woman presented with bleeding, abdominal pain, and dyspnea. Imaging revealed a large left adnexal mass with AFP of 2062 ng/mL. Surgical cytoreduction confirmed an International federation of Gynecology and Obstetrics (FIGO) stage II yolk sac tumor involving the left ovary and right fallopian tube with omental implants. Postoperative AFP normalized, and the patient has undergone adjuvant BEP chemotherapy and remains under clinical surveillance.
Conclusion: This case highlights a rare presentation of ovarian yolk sac tumor in a postmenopausal patient with involvement of the contralateral fallopian tube, a combination that, to our knowledge, has been described only in isolated cases in the literature. Germ cell tumors should be included in the differential diagnosis of adnexal masses in older women, particularly when APF is elevated, and multidisciplinary management is essential to optimize outcomes.
Keywords: Alpha-fetoprotein, Fallopian tube, Ovarian, Postmenopausal, Yolk sac tumor
SUPPORTING INFORMATION
Acknowledgments
The authors thank the medical and nursing staff involved in the patient’s care, as well as the patient, for consenting to share her case for educational and scientific purposes.
The authors also acknowledge the use of artificial intelligence (AI)-assisted writing tools in the preparation of this manuscript. All AI-generated content was reviewed, edited, and approved by the authors, who take full responsibility for the accuracy and integrity of the published work.
Gloria LópezPérez - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Pablo Eulalio Ruiz Iglesias - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Raquel González Marín - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Emilia Hernández Nieto - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
María del Carmen Torres Caballero - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Guaranter of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2026 Gloria López Pérez et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
