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Case Report
Rheumatic heart disease in a patient with Marfan’s syndrome
1 Consultant Cardiologist, Internal Medicine Department, LAUTECH Teaching Hospital, Ogbomoso, Oyo State, Nigeria
2 Junior Registrar, Internal Medicine Department, LAUTECH Teaching Hospital, Ogbomoso, Oyo State, Nigeria
3 Professor of Medicine, Former provost, College of health Sciences, Head, cardiology unit, Internal Medicine Department, LAUTECH Teaching Hospital, Ogbomoso, Oyo State, Nigeria
Address correspondence to:
Olawale Mathias Akinlade
Cardiology Unit, Internal Medicine Department, LAUTECH Teaching Hospital, Ogbomoso, Oyo State, Postal code: +234,
Nigeria
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Article ID: 101020Z01OA2019
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How to cite this article
Akinlade OM, Yusuf AM, Akintunde AA, Opadijo OG. Rheumatic heart disease in a patient with Marfan’s syndrome. Int J Case Rep Images 2019;10:101020Z01OA2019.ABSTRACT
Marfan’s syndrome (MFS) is an inheritable autosomal dominant disorder affecting the connective tissue with defect isolated to FBN1 gene on chromosome 15, which codes for the connective tissue protein fibrillin. The malfunctioning of the above gene has been implicated with predominantly heart, musculoskeletal and ocular problems. The main cardiovascular manifestations in Marfan’s syndrome are mitral valve prolapse and aortic dilation which according to literature database have a prevalence of 76% and 62% respectively in adult population with Marfan’s syndrome. The case reported is that of a patient who presented with features of congestive heart failure secondary to rheumatic heart disease who also has clinical and echocardiographic features of Marfan’s syndrome. This report highlights the coexistence of two major cardiovascular abnormalities, one inherited and the other one acquired which had not been previously reported to the best of our knowledge so far in Nigeria and indeed West Africa.
Keywords: Aortic dilatation, Marfan’s syndrome, Mitral valve prolapse, Rheumatic heart disease
SUPPORTING INFORMATION
Author Contributions
Olawale Mathias Akinlade - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Abiola M. Yusuf - Interpretation of data, Drafting the article, Final approval of the version to be published
Adeseye Abiodun Akintunde - Substantial contributions to conception and design, Acquisition of data, Interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
Oladimeji George Opadijo - Interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
Guaranter of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2019 Akinlade Olawale Mathias et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
