 |
Case Series
Bone metaplasia with functional bone marrow in arterial calcification of two autopsied patients
1 General Pathology Discipline, Federal University of Triângulo Mineiro (UFTM), Uberaba, Minas Gerais, Brazil
Address correspondence to:
Mara Lúcia da Fonseca Ferraz
General Pathology Discipline, Federal University of Triângulo Mineiro, Avenida Frei Paulino, n. 30, Bairro Abadia, CEP: 38025-180, Uberaba, Minas Gerais,
Brazil
Message to Corresponding Author
Article ID: 101105Z01MG2020
Access full text article on other devices
Access PDF of article on other devices
How to cite this article
Oliveira MS, Torquato BGS, dos Reis Monteiro MLG, Rezende IPB, Dutra JNS, da Fonseca Ferraz ML. Bone metaplasia with functional bone marrow in arterial calcification of two autopsied patients. Int J Case Rep Images 2020;11:101105Z01MG2020.ABSTRACT
Osteoid metaplasia with functioning marrow is a rare pathological process in arterial calcifications, associated to the asymptomatic development of atherosclerotic plaques. Objective: To describe morphological aspects of bone metaplasia in arterial calcifications and its pathogenesis in two cases. Macroscopic examination of iliac arteries was performed and fragments of approximately 2 cm of the right and left iliac arteries were collected for microscopic analysis of atherosclerosis. These fragments were processed histologically and stained with hematoxylin and eosin (HE). A pronounced atherosclerosis, characterized by diffuse atheroma plaques and foci of calcifications, was evidenced. In both cases, in intima layer of atherosclerotic plaque in right iliac artery, a dilatation, and the presence of bone metaplasia with bone trabeculae, calcifications, and functioning bone marrow with red blood cells and megakaryocytes were observed. Due to the rarity of this lesion, its description allows better characterization of morphological data and pathogenesis.
Keywords: Autopsy, Bone marrow, Calcinosis, Iliac artery
SUPPORTING INFORMATION
Acknowledgments
Financial Support: Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG), and Fundação de Ensino e Pesquisa de Uberaba (FUNEPU).
Author ContributionsMariana Silva Oliveira - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Bianca Gonçalves Silva Torquato - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Maria Luiza Gonçalvesdos Reis Monteiro - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Ian Pedro Borges Rezende - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Júlia Neves Silva Dutra - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Mara Lúcia da Fonseca Ferraz - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Guaranter of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2020 Mariana Silva Oliveira et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
