 |
Case Report
Dermatomyofibroma in a young Irish female
1 Department of Dermatology, Galway University Hospital, Galway City, Ireland
2 Department of Histopathology, Galway University Hospital, Galway City, Ireland
3 Consultant Dermatologist, Department of Dermatology, Galway University Hospital, Galway City, Ireland
Address correspondence to:
Amy Ridge
Department of Dermatology, Galway University Hospital, Newcastle Road, Galway City,
Ireland
Message to Corresponding Author
Article ID: 101128Z01AR2020
Access full text article on other devices
Access PDF of article on other devices
How to cite this article
Ridge A, Heuston G, Kilmartin D, Marren P, Tietz B, Laing ME. Dermatomyofibroma in a young Irish female. Int J Case Rep Images 2020;11:101128Z01AR2020.ABSTRACT
Introduction: Dermatomyofibroma represents a rare, benign mesenchymal neoplasm of fibroblast and myofibroblast differentiation. They are most often found in young adult women and male children.
Case Report: We report a case of dermatomyofibroma, which to our knowledge is the first reported case in Ireland. Histologically, dermatomyofibroma typically demonstrates proliferation of uniform spindle cells arranged as well-defined intersecting fascicles, parallel to the epidermal surface. The tumor respects skin appendages and the epidermis remains unchanged. Elastic fibers are preserved. With regard to immunohistochemistry, the spindle cells are variably positive when stained with antibodies directed against actin and negative for desmin, S100, and CD34. There are no reports of metastases or recurrence of this benign tumor in the literature.
Conclusion: Dermatomyofibroma typically occurs in young females and represents a benign tumor with no reported potential to recur or metastasize. It should be considered in the differential by the dermatologist when evaluating lesions resembling large dermatofibroma.
Keywords: Dermatomyofibroma, Fibroblasts, Myofibroblasts
SUPPORTING INFORMATION
Author Contributions
Amy Ridge - Drafting the article, Final approval of the version to be published
Grainne Heuston - Acquisition of data, Drafting the article, Final approval of the version to be published
Darren Kilmartin - Acquisition of data, Drafting the article, Final approval of the version to be published
Pauline Marren - Acquisition of data, Revising it critically for important intellectual content, Final approval of the version to be published
Birgit Tietz - Acquisition of data, Revising it critically for important intellectual content, Final approval of the version to be published
Mary Laing - Substantial contributions to conception and design, Revising it critically for important intellectual content, Final approval of the version to be published
Guaranter of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2020 Amy Ridge et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
