 |
Case Report
Favorable response to cyclophosphamide in a patient with refractory Guillain–Barre syndrome associated with chronic lymphocytic leukemia
1 Haematology Department, University Hospital Southampton, Southampton, UK
2 Neurology Department, University Hospital Southampton, Southampton, UK
3 Intensive Care Department, University Hospital Southampton, Southampton, UK
Address correspondence to:
Nicholas Lafferty
Haematology Department, Southampton General Hospital, Southampton, SO16 6YD,
UK
Message to Corresponding Author
Article ID: 101286Z01NL2022
Access full text article on other devices
Access PDF of article on other devices
How to cite this article
Lafferty N, Sehgal T, Duncombe A, Katifi H, Allen D, Karar S. Favorable response to cyclophosphamide in a patient with refractory Guillain–Barre syndrome associated with chronic lymphocytic leukemia. Int J Case Rep Images 2022;13:101286Z01NL2022.ABSTRACT
Introduction: Neurological symptoms may occur in patients with chronic lymphocytic leukemia (CLL) through a variety of etiologies. However, autoimmune disorders involving the nervous system, such as Guillain–Barre syndrome (GBS), have only rarely been reported in patients with CLL, despite the well-established association between CLL and other autoimmune phenomena. Previous reports demonstrate no consistent approach to management of these cases.
Case Report: Here we report a case of severe GBS associated with newly diagnosed CLL. The patient did not respond to initial therapy with intravenous immunoglobulin, plasmapheresis, and corticosteroids, but demonstrated a rapid neurological and hematological improvement following cyclophosphamide infusion.
Conclusion: Here, for the first time, we describe the successful treatment of CLL-associated GBS using cyclophosphamide.
Keywords: B cell, Chronic, Cyclophosphamide, Guillain–Barre syndrome, Leukemia, Lymphocytic
SUPPORTING INFORMATION
Author Contributions
Nicholas Lafferty - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Tushar Sehgal - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Andrew Duncombe - Acquisition of data, Final approval of the version to be published
Haider Katifi - Acquisition of data, Analysis of data, Interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
David Allen - Acquisition of data, Analysis of data, Interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
Shoura Karar - Acquisition of data, Revising it critically for important intellectual content, Final approval of the version to be published
Guaranter of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2022 Nicholas Lafferty et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
