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Case Report
Histopathologic diagnosis of aggressive angiomyxoma following removal of an asymptomatic, stable vulvar mass
1 4th Year Medical Student, Wayne State University, School of Medicine, Detroit, Michigan, United States of America
2 MD, Obstetrics-Gynecology, Detroit Medical Center/Wayne State University, Detroit, Michigan, United States of America
3 DO, Obstetrics-Gynecology, Detroit Medical Center/Wayne State University, Commerce Charter Township, Michigan, United States of America
Address correspondence to:
Laura Collins
MD, 3876 Thomas Ave, Berkley, Michigan 48072,
United States of America
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Article ID: 100057Z08MM2020
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McNitt M, Collins L, Malayev Y. Histopathologic diagnosis of aggressive angiomyxoma following removal of an asymptomatic, stable vulvar mass. J Case Rep Images Obstet Gynecol 2020;6:100057Z08MM2020.ABSTRACT
Introduction: Aggressive angiomyxoma (AAM) is a rare, locally aggressive, benign tumor usually found in the female pelvis.
Case Report: We present a 42-year-old Caucasian female undergoing removal of a non-enlarging, painless vulvar mass at time of hysteroscopic endometrial ablation for abnormal uterine bleeding. The patient had a past medical history notable for multiple malignant melanomas. Past surgical history included three low transverse cesarean sections, postpartum tubal ligation, and three wide excisions of melanomas. Family history was negative for dermatologic disease or cancers. The mass had been present for over two years; she desired removal for cosmetic purposes. At the time of surgery, the patient was asymptomatic and physical examination revealed a soft, mobile, approximately 2 cm, non-tender right labial mass. Previous ultrasound report described the mass as 2 × 2 cm and solid-appearing. During the surgery, a 5 × 2.6 × 1.4 cm irregular mass with soft, spongy contents was removed intact via incision followed by blunt and sharp dissection. Pathology of the specimen revealed AAM, with extension of tumor to the surgical margins. Histology and immunohistochemistry reports were consistent with previous descriptions of AAM tumors.
Conclusion: While AAM is uncommon, the diagnosis should be considered for any patient presenting with an asymptomatic growth in the vulvovaginal region. Treatment should involve surgical excision, and the patient should be closely followed for recurrence. The case reported here is a unique presentation of a small, stable AAM in a patient with a history of multiple episodes of malignant melanoma in the past.
Keywords: Aggressive angiomyxoma, Asymptomatic, Benign, Vulva
SUPPORTING INFORMATION
Acknowledgments
The authors would like to thank Dr. Aulicino, the pathologist, for his help on this case.
Author ContributionsMegan McNitt - Acquisition of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Laura Collins - Substantial contributions to conception and design, Analysis of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Yuliya Malayev - Acquisition of data, Interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
Guaranter of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2020 Megan McNitt et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
