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Case Report
STK11 mutation and fallopian tube histology indicating hysterectomy and bilateral salpingo-oophorectomy in a 40-year-old female
1 Department of Pathology at Texas Tech Health Sciences Center, El Paso, TX, USA
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Jude Abadie
Department of Pathology at Texas Tech Health Sciences Center, El Paso, TX,
USA
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Article ID: 100195Z08RG2025
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Gamez R, Partida A, Abadie J. STK11 mutation and fallopian tube histology indicating hysterectomy and bilateral salpingo-oophorectomy in a 40-year-old female. J Case Rep Images Obstet Gynecol 2025;11(1):29–34.ABSTRACT
Introduction: Metaplastic fallopian tube changes are usually related to inflammation, infection, and/or deleterious STK11 mutations. While these fallopian tube changes have low incidence, they are clinically important to accurately identify premalignant, somatic pathogenesis in patients with Peutz–Jeghers syndrome (PJS).
Case Report: Here we describe a case of a 40-year-old female, with a chronic history of menometrorrhagia, who underwent prophylactic total hysterectomy with bilateral salpingo-oophorectomy (TAH-BSO) due to risk of non-epithelial ovarian cancer associated with a de novo, germline heterozygous STK11 exon 6 deletion. The patient’s father had colorectal carcinoma, her mother had endometrial cancer, and her older sister had breast cancer. The patient’s colonoscopy, screening mammograms, endometrial biopsy, and PAP smears were all negative. Sample morphology was negative for high-grade dysplasia and malignancy; however, prophylactic TAH-BSO was performed due to the patient’s positive carrier status, increased risk for gynecological cancers, and mucinous tumors.
Conclusion: Currently, there are no studies demonstrating how exclusion of secondary findings in PJS supports prophylactic, life-saving management in a subset of patients with strong genetic predisposition and a family history of breast cancer. Hysterectomy is generally considered a last resort after other treatments have failed in cases of heavy menstrual bleeding. As evident in this case of combined PJS and menorrhagia, a prophylactic surgical procedure was clinically indicated.
Keywords: Fallopian tube, Hysterectomy, Peutz–Jeghers syndrome, STK11 mutation, Salpingo-oophorectomy
SUPPORTING INFORMATION
Author Contributions
Roberto Gamez - Substantial contributions to conception and design, Interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
Alejandro Partida - Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Jude Abadie - Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Guaranter of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2025 Roberto Gamez et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
