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Case Report
Successful penicillin desensitization in a pregnant woman with latent syphilis and penicillin allergy
1 MBBS, Senior House Officer, Department of Obstetrics and Gynecology, Queen Elizabeth Hospital, St Michael, Barbados
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Keturah Murray
Queen Elizabeth Hospital, Martindales Road, St Michael,
Barbados
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Article ID: 100224Z08KM2026
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How to cite this article
Murray K. Successful penicillin desensitization in a pregnant woman with latent syphilis and penicillin allergy. J Case Rep Images Obstet Gynecol 2026;12(1):14–17.ABSTRACT
Syphilis during pregnancy has a high risk of congenital transmission with disastrous fetal consequences. The only proven effective therapy for gestational syphilis is benzathine penicillin, as its bioavailability ensures adequate treatment for both the mother and the fetus. Here we report a case of a 30-year-old pregnant woman, with syphilis and a penicillin allergy, who was safely and successfully desensitized using a 4-hour oral protocol in the intensive care unit and subsequently received benzathine penicillin G.
Keywords: Penicillin desensitization, Pregnancy, Syphilis
SUPPORTING INFORMATION
Author Contributions
Keturah Murray - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Guaranter of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2026 Keturah Murray. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
